High-throughput imaging of GABA fluorescence as a functional assay for variants in the neurodevelopmental gene, SLC6A1
Christopher Michael McGraw, Guoqi Zhang, Gillian Prinzing, Kimberly Wiltrout, Annapurna Poduri
The paper develops a high-content fluorescence imaging assay to assess GABA transporter function in SLC6A1 variants, showing strong correlation with radioactive assays and potential for high-throughput screening.
bioRxiv · Nov 6, 2025 · PreprintNeuroscience