Christopher Michael McGraw

The paper develops a high-content fluorescence imaging assay to assess GABA transporter function in SLC6A1 variants, showing strong correlation with radioactive assays and potential for high-throughput screening.

The paper investigates the functional role of recursive splicing in CADM2, showing that its deletion leads to altered gene expression and behavioral changes in neurodevelopmental disorders.

The paper evaluates scn1lab loss-of-function in zebrafish using calcium and movement data, finding enhanced proconvulsant sensitivity as a reliable indicator despite suppressive effects from genetic background and pigmentation.

This paper develops a machine learning method combining movement and calcium fluorescence data to detect seizure-like activity in zebrafish, enabling high-throughput, low-replicate screening of anti-seizure compounds.

The paper generates zebrafish models of candidate human epilepsy genes and identifies five genes associated with seizure-like behavior and hyperexcitability.

In a mouse model of Rett syndrome, counterbalancing mosaic LOF with complementary mosaic GOF improves phenotypic outcome.

This study shows that both mosaic and non-mosaic pcdh19 mutations in zebrafish lead to neuronal hyperexcitability, challenging the idea that mosaicism alone causes PCDH19-related epilepsy.