Negative regulation of miRNAs sorting in EVs: the RNA-binding protein PCBP2 impairs SYNCRIP-mediated miRNAs EVs loading
Francesco Marocco, Sabrina Garbo, Claudia Montaldo, Alessio Colantoni, Luca Quattrocchi, Gioele Gaboardi, Giovanna Sabarese, Carla Cicchini, Mario Lecce, Alessia Carnevale, Rossella Paolini, Gian Gaetano Tartaglia, Cecilia Battistelli, Marco Tripodi
The paper identifies PCBP2 as an inhibitor of SYNCRIP-mediated miRNA loading into EVs through direct interaction with an intracellular retention motif.
eLife · Jul 2, 2025Peer-reviewedMolecular Biology