Alessio Colantoni

This study investigates CHD8's role in female neuronal differentiation using multi-omics analysis, revealing its impact on chromatin structure and gene regulation in mouse models.

scRAPID-web predicts protein-RNA interactions from scRNA-seq data across eight organisms, offering GRN inference and visualization tools.

This study shows that LBR nucleoplasmic domains regulate X-chromosome solubility and nuclear organization during neural differentiation in mouse cells.

The paper shows that dilncRNA, DROSHA, and DICER control DISC by recruiting BMI1 and promoting H2A-K119 ubiquitination at DNA double-strand breaks.

This study shows RNA binding alters the structure, function, and stability of alpha-synuclein fibrils, suggesting RNA as an active co-factor in amyloid formation.

The paper generates a complete diploid genome assembly for RPE-1 cells and uses it as a matched reference to improve multi-omics data analysis and identify haplotype-specific epigenetic variation.

The paper identifies PCBP2 as an inhibitor of SYNCRIP-mediated miRNA loading into EVs through direct interaction with an intracellular retention motif.

This study shows that RNase H1 reduces DNA damage and improves SMA-like symptoms in a Drosophila model by resolving RNA:DNA hybrids caused by SMN deficiency.

This paper identifies low-complexity repeats as key drivers of RNA-RNA interactions and introduces RIME, a deep learning model that outperforms traditional methods in predicting these interactions.

This study uses patient-derived iPSCs with a GNAO1 variant to show altered neuronal differentiation and function in cortical neurons.

This study develops scRAPID, a pipeline that predicts protein-RNA interactions from single-cell transcriptomic data, showing comparable or better performance than transcription factor-target interaction prediction.

This study shows that HuD overexpression impairs neuromuscular junctions and induces apoptosis in ALS models, while its knockdown rescues these defects.

PRALINE is a database that catalogs proteins and RNAs in biological condensates, their interactions, and the impact of single-nucleotide variants on condensate properties.

The paper develops an in vitro protocol to generate human Pharyngeal Endoderm cells and uses multi-omics analysis to reveal Retinoic Acid's role in their epigenetic and transcriptional development.

This study shows TGS1 is essential for snRNA 3' end processing and its loss causes neurodegeneration, which can be mitigated by human TGS1 expression in model organisms.