Patient-derived Cellular Models of Polygenic Scores: Application to Long QT Syndrome
Devyn Mitchell, Matthew J. O’Neill, Loren R. Vanags, Nidhi Patel, Theresa Strickland, Giovanni Davagustto, Moore Benjamin Shoemaker, Joe‐Elie Salem, Brett M. Kroncke
The paper uses patient-derived iPSC-CMs to show that polygenic scores influence cardiac electrophysiology and drug response in Long QT Syndrome.
bioRxiv · Aug 5, 2025 · PreprintGenetics