The replication checkpoint couples fork progression to the release of transcribed genes from nuclear pores
Giovanni Nigro, Jonathan Heuzé, Salomé Grassin, Lucie Fasolo, Antoine Barthe, Philippe Pasero, Jérôme Poli
This study shows that replication stress causes genes to detach from nuclear pores, coordinated with fork progression, and that checkpoint kinases Mec1/ATR and Rad53/CHK1 regulate this process in a stepwise manner.
bioRxiv · Oct 9, 2026 · PreprintGenetics