Philippe Pasero

The paper shows that the replication checkpoint reduces transcription to prevent fork stalling and replication stress in yeast and human cells.

This study shows that replication stress causes genes to detach from nuclear pores, coordinated with fork progression, and that checkpoint kinases Mec1/ATR and Rad53/CHK1 regulate this process in a stepwise manner.

The paper develops iCoRD to rapidly deliver RNase H1 in live cells and shows it affects specific RNA:DNA hybrids and replication fork stability.

The paper shows condensin and topoisomerases work together to relieve topological stress at stalled replication forks in yeast and human cells.

This study shows that Slx4 and Fun30/SMARCAD1 locally dampen the S-phase checkpoint to promote replication fork protection and completion in response to Top1-DNA crosslinks.

This study shows that rapid delivery of RNase H1 rescues replication fork progression under stress without affecting R-loops.

This study shows that MRE11 promotes oncogene-induced senescence by slowing replication forks and activating the cGAS-STING pathway, while TREX1 prevents it by degrading cytosolic DNA.

The paper shows Sen1 resolves transcription-driven conflicts and maintains genomic stability by terminating non-coding transcription and resolving R-loops.

The paper shows that Mus81 is essential for resolving recombination intermediates during replication restart in G2/M phase, independent of DNA supercoiling and crosslinks.

qDSB-Seq quantifies absolute DNA double-strand break frequencies and their genomic coordinates across samples and organisms.