Author
Centre National de la Recherche ScientifiqueORCID 0009-0008-2870-521XUnclaimed ORCID profile · follow to get notified of new preprints
3 papers
Recent·Most cited
Jonathan Heuzé, Salomé Grassin, Philippe Pasero, Jérôme Poli
The paper shows that the replication checkpoint reduces transcription to prevent fork stalling and replication stress in yeast and human cells.
Giovanni Nigro, Jonathan Heuzé, Salomé Grassin…·Jérôme Poli
This study shows that replication stress causes genes to detach from nuclear pores, coordinated with fork progression, and that checkpoint kinases Mec1/ATR and Rad53/CHK1 regulate this process in a stepwise manner.
Hervé Técher, Diyavarshini Gopaul, Jonathan Heuzé…·Philippe Pasero
This study shows that MRE11 promotes oncogene-induced senescence by slowing replication forks and activating the cGAS-STING pathway, while TREX1 prevents it by degrading cytosolic DNA.