Perturbation-guided mapping of colorectal cancer cell states to causal mechanisms
Soroor Hediyeh-zadeh, Tzen S. Toh, Olli Dufva, Giuseppe Serra, Rashika Jakhmola, Camille Fourneaux, Gonçalo Pinto, Zijian Fang, Gabriele Picco, Amanda J. Oliver, Rasa Elmentaite, Till Richter, Ken To, J. Patrick Pett, Sarah Amalia Teichmann, , Mathew J. Garnett
This paper develops a continual learning framework to map colorectal cancer cell states to causal mechanisms through integration of single-cell data and perturbation experiments.
bioRxiv · Mar 24, 2026 · PreprintGenomics