CREG1 promotes autophagy and protects the heart against nutritional stress-induced injury and age-associated hypertrophy, fibrosis and diastolic dysfunction
Yanmei Qi, Russell Pepe, Glenn Tejeda, Yechaan Joo, NaYoung Yang, Kevin B. Hayes, Saum A. Rahimi, Zhongren Zhou, Shaohua Li, Leonard Y. Lee
This study shows that CREG1 promotes autophagy and protects the heart from nutritional stress and age-related damage by maintaining autophagic flux and preventing mitochondrial dysfunction.
bioRxiv · Nov 11, 2025 · PreprintCell Biology