BioinformaticsTranslational OncologyPeer-reviewed
AlphaMissense pathogenicity scores predict response to immunotherapy and enhances the predictive capability of tumor mutation burden
David Adeleke, Adewale Oluwaseun Fadaka, Nicole Remaliah Samantha Sibuyi…·Rick J. Jansen
The paper introduces AlphaTMB, a composite biomarker combining tumor mutation burden with pathogenicity scores, showing improved survival prediction in immunotherapy response.
DOI 10.1016/j.tranon.2026.102697