Rick J. Jansen

The paper maps cis- and trans-eQTLs in blood samples to infer gene regulatory networks and prioritize trait-relevant pathways.

The paper introduces AlphaTMB, a composite biomarker combining tumor mutation burden with pathogenicity scores, showing improved survival prediction in immunotherapy response.

This study compares host immune responses to SARS-CoV-2 Delta and Omicron variants using RNA-seq data, identifying distinct hub genes associated with different immune pathways and outcomes.

The paper compares bulk RNA-seq and deconvolution results from paired pancreatic cancer samples in the same patients, finding variability in cell type proportions but no significant gene expression differences.

The paper benchmarks 49 algorithms for predicting B. pertussis vaccination outcomes, finding that purpose-built models outperform literature-based ones due to better handling of nonlinearities and data preprocessing.

This study identifies spaceflight-induced changes in gut microbiota and host gene expression in mice, suggesting altered host-microbiome interactions contribute to spaceflight-related pathologies.