Proton-gating of opioid receptors and isoform functionality
Kyutae David Lee, Gorav Surana, Sam Taylor, Daniel G. Isom
This study shows opioid receptors act as proton-gated coincidence detectors, with a conserved aspartic acid residue critical for pH sensing and agonist activation.
bioRxiv · May 29, 2026 · PreprintMolecular Biology