Commensal-derived short-chain fatty acids disrupt lipid membrane homeostasis in Staphylococcus aureus
Joshua R. Fletcher, Lisa A. Hansen, Julia R. Hoyser, Allison E. Hanna, Richard Martinez, Christian D. Freeman, Niall Thorns, Mitchell R. Penningroth, Alex R. Villarreal, Grace A. Vogt, Matthew A. Tyler, Kelly Marie Hines, Ryan C. Hunter
This study shows that SCFAs from commensal bacteria impair S. aureus growth and virulence by disrupting BCFA metabolism and increasing antimicrobial sensitivity.
mBio · Nov 28, 2025Peer-reviewedMicrobiology