Cardiac Extracellular Matrix derived from younger animals stabilizes macrophage inflammatory polarization through modulation of the interferon signaling pathway
Keely Nugnes, Grace Costello, Nora McCarey, Ella Canas, Lauren Deems Black
The paper shows that neonatal cardiac ECM reduces macrophage inflammation by suppressing interferon signaling, unlike adult ECM.
bioRxiv · Sep 10, 2026 · PreprintCell Biology