Lauren Deems Black

T cell-derived IFNγ instructs ECM crosslinking by cardiac fibroblasts through LOXL3 in experimental cardiometabolic HFpEF

This study identifies T cell-derived IFNγ as a driver of ECM stiffening in HFpEF via LOXL3 in cardiac fibroblasts, showing therapeutic potential for targeting this pathway.

Cardiac Extracellular Matrix derived from younger animals stabilizes macrophage inflammatory polarization through modulation of the interferon signaling pathway

The paper shows that neonatal cardiac ECM reduces macrophage inflammation by suppressing interferon signaling, unlike adult ECM.

A Cone-Plate Bioreactor for Applying Physiologically Derived Shear Stress Waveforms to Study Endothelial Mechanotransduction and Cardiac Cell Signaling

This paper introduces a cone-plate bioreactor that applies controlled shear stress to endothelial cells and cardiac tissues, showing increased cell alignment and cardiomyocyte proliferation under pulsatile shear.

Identification and characterization of a Fibrillin-1 derived matrikine for cardiac regeneration and repair

This study identifies a fibrillin-1 derived peptide that enhances cardiomyocyte proliferation and reduces fibroblast activation, suggesting potential as a cardiac regeneration therapy.

Non Newtonian Blood Rheology Significantly Alters Hemodynamic Predictions During Cardiac Looping: A Computational Study

This study evaluates how non-Newtonian blood rheology affects hemodynamic predictions during cardiac looping using computational models.

Functional maturation of human neural stem cells in a 3D bioengineered brain model enriched with fetal brain matrix

This study shows that using fetal brain matrix in 3D cultures enhances the functional differentiation of human neural stem cells into neurons and astrocytes.