An immunocompetent model of MCPyV-driven Merkel cell carcinoma reveals tumor evolution under immune selection
James M. Regan, Xiaomei Li, Mykaela Salvacion, Tiana T. Luo, Meng Jia, Grace Ho, Jonathan R. Xu, Shujing Liu, Zhi Huang, Xiaowei Xu, Jianxin You
This study shows that MCPyV-driven tumors evolve immune-evasive traits under immune pressure, favoring sT over LTT expression, using a mouse model of Merkel cell carcinoma.
bioRxiv · Jul 13, 2026 · PreprintCancer Biology