Author

Jianxin You

University of PennsylvaniaORCID 0000-0002-9478-2159Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2

Frequent Co-Authors

Tiana T. Luo· 3 shared James M. Regan· 2 shared Taylor E. SenayiD· 2 shared Xiaomei LiiD· 2 shared Ahmed DiabiD· 1 shared Alexander LiniD· 1 shared Alexander T. PearsoniD· 1 shared David ShimunoviD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersMicrobiology

Tiana T. Luo

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

An immunocompetent model of MCPyV-driven Merkel cell carcinoma reveals tumor evolution under immune selection

James M. Regan, Xiaomei Li, Mykaela Salvacion, Tiana T. Luo, Meng Jia, Grace Ho, Jonathan R. Xu, Shujing Liu, Zhi Huang, Xiaowei Xu, Jianxin You

This study shows that MCPyV-driven tumors evolve immune-evasive traits under immune pressure, favoring sT over LTT expression, using a mouse model of Merkel cell carcinoma.

bioRxiv · Jul 13, 2026 · PreprintCancer Biology

A short intrinsically disordered domain of MCPyV ALTO regulates host TBK1 signaling and MCPyV latency

Taylor E. Senay, Xiaomei Li, Sneha G. Shirhattikar, Tiana T. Luo, Jianxin You

The paper identifies a short intrinsically disordered domain in MCPyV ALTO, LIT, that regulates TBK1 signaling and MCPyV latency by inhibiting TBK1 activation.

bioRxiv · Aug 9, 2025 · PreprintMicrobiology

Association of oropharyngeal cancer recurrence with tumor-intrinsic and immune-mediated sequelae of reduced genomic instability

Malay Kumar Sannigrahi, Lovely Raghav, Dominick J. Rich, Travis Parke Schrank, Joseph A. Califano, John Nicholas Lukens, Lova Sun, Iain M. Morgan, Roger B. Cohen, Alexander Lin, Xinyi Liu, Eric J. Brown, Jianxin You, Lisa J. Mirabello, Sambit Kumar Mishra, , Devraj Basu

This study identifies molecular traits distinguishing HPV+ oropharyngeal cancer recurrence, showing reduced genomic instability contributes to tumor progression and immune suppression.

JNCI Journal of the National Cancer Institute · Mar 11, 2025Peer-reviewedCancer Biology

Merkel cell polyomavirus protein ALTO modulates TBK1 activity to support persistent infection

Ranran Wang, Taylor E. Senay, Tiana T. Luo, Wei Liu, James M. Regan, Nicholas J. H. Salisbury, Denise A. Galloway, Jianxin You

This study identifies MCPyV protein ALTO as a factor that modulates the STING-TBK1 pathway to limit viral replication and maintain persistent infection.

PLoS Pathogens · Jul 29, 2024Peer-reviewedMicrobiology