Discovery and Preclinical Validation of a Clinically Optimized Mitochondrial Complex I Modulator for Alzheimer's Disease
Sergey Trushin, Thi Kim Oanh Nguyen, Mark Ostroot, Alexander S. Galkin, Toshihiko Nambara, Wenyan Lü, Takahisa Kanekiyo, Graham Johnson, Eugenia V. Trushina
This paper describes the discovery and validation of C273, a mitochondrial complex I modulator that reduces Alzheimer's disease pathology by enhancing cellular resilience through AMPK-mediated pathways.
bioRxiv · Apr 14, 2026 · PreprintNeuroscience