Beyond Better Models: Barriers and a Path Forward in Generalisable TCR Antigen Specificity Prediction
Ilija Ilievski, Agne Antanaviciute, Graham Ogg, Hashem Koohy
This paper identifies barriers to generalisable TCR:pMHC prediction and proposes solutions through data analysis, evaluation setup, and metric alignment.
bioRxiv · Oct 22, 2026 · PreprintImmunology