Durability of DNA-LNP and mRNA-LNP Vaccine-Induced Immunity Against SARS-CoV-2 XBB.1.5
Levi A. Tamming, Casey Lansdell, Wanyue Zhang, Diana Duque, Jegarubee Bavananthasivam, Grant E. Frahm, Annabelle Pfeifle, Sathya N. Thulasi Raman, Jianguo Wu, Caroline Gravel, Andrew Stalker, Matthew Stuible, Yves Durocher, Wangxue Chen, Lisheng Wang, , Xuguang Li
This study compares DNA-LNP and mRNA-LNP vaccines against SARS-CoV-2 XBB.1.5, showing DNA-LNPs maintain durable immunity six months post-boost while mRNA-LNPs show waning protection.
npj Vaccines · Jan 31, 2026Peer-reviewedImmunology