Long-Term Oral Tamoxifen Administration Decreases Brain Derived Neurotrophic Factor in the Hippocampus of Female Long-Evans Rats
Laura E. Been, Amanda R. Halliday, Sarah M. Blossom, Elena M. Bien, Anya G. Bernhard, Grayson E. Roth, Karina I. Domenech Rosario, Karlie Pollock, Petra E. Abramenko, Leily Marieh Behbehani, Gabriel J. Pascal, Mary Ellen Kelly
This study shows that long-term oral tamoxifen reduces BDNF in the hippocampus of female rats, suggesting a potential mechanism for cognitive side effects in patients.
Cancers · Mar 31, 2024Peer-reviewedNeuroscience