Distinct allosteric networks in CDK4 and CDK6 in the cell cycle and in drug resistance
Wengang Zhang, Devin A. Bradburn, Gretchen Heidebrink, Yonglan Liu, Hyunbum Jang, Ruth Nussinov, Mardo Kõivomägi
This study identifies distinct allosteric networks in CDK4 and CDK6 that explain their differential kinase activity, inhibitor binding, and roles in cell cycle regulation and drug resistance.
Journal of Molecular Biology · Apr 2, 2025Peer-reviewedMolecular Biology