Uncovering cancer dependencies in peptide-interacting protein pockets
Mihkel Örd, Liz Kogan, Devin A. Bradburn, Michelle Leiser, Mardo Kõivomägi, Norman E. Davey, Pau Creixell
The paper screens peptide-binding pockets across cancer cell lines to identify therapeutic vulnerabilities and dependencies, finding that peptide inhibition can reveal hidden dependencies and enhance drug efficacy.
bioRxiv · Mar 15, 2026 · PreprintCancer Biology