Targeted Epigenetic Modulation Outperforms Nuclease- and Deaminase-Based Editing for Durable Pcsk9 Silencing in a Clinically Relevant Delivery System
Anusorn Mudla, Dominic Dimitri Quintana, Christian Flynn Atallah, Lindsey Renee Savoy, Angel I. Leu, Thanhchau Dam, Grishma Acharya, Kumar Rajappan, Padmanabh Chivukula
This study compares epigenetic gene editing, base editing, and siRNA for PCSK9 suppression, finding epigenetic editing provides the most durable and efficient PCSK9 repression in mice.
bioRxiv · Mar 23, 2026 · PreprintMolecular Biology