Author

Kumar Rajappan

Arcturus Therapeutics (United States)ORCID 0000-0002-7140-0103Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Organism:mouse· 1

Frequent Co-Authors

Angel I. Leu· 1 shared Anusorn MudlaiD· 1 shared Christian Flynn Atallah· 1 shared Dominic Dimitri QuintanaiD· 1 shared Grishma Acharya· 1 shared Lindsey Renee SavoyiD· 1 shared Padmanabh ChivukulaiD· 1 shared Thanhchau DamiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 28 mutual co-author links

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1 shared paperMolecular Biology

Angel I. Leu

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1 paper

Recent·Most cited

Targeted Epigenetic Modulation Outperforms Nuclease- and Deaminase-Based Editing for Durable Pcsk9 Silencing in a Clinically Relevant Delivery System

Anusorn Mudla, Dominic Dimitri Quintana, Christian Flynn Atallah, Lindsey Renee Savoy, Angel I. Leu, Thanhchau Dam, Grishma Acharya, Kumar Rajappan, Padmanabh Chivukula

This study compares epigenetic gene editing, base editing, and siRNA for PCSK9 suppression, finding epigenetic editing provides the most durable and efficient PCSK9 repression in mice.

bioRxiv · Mar 23, 2026 · PreprintMolecular Biology