Temporal constraints on enhancer usage shape the regulation of limb gene transcription
Raquel Rouco, Antonella Rauseo, Fabrice Darbellay, Guillaume Sapin, Olimpia Bompadre, Lucille Lopez‐Delisle, Guillaume Andrey
The paper investigates how temporally restricted enhancer repertoires regulate gene expression during limb development in mice and shows that enhancer-promoter interactions dynamically change over time.
Nature Communications · Jan 12, 2026Peer-reviewedDevelopmental Biology