Guillaume Andrey

The paper investigates how temporally restricted enhancer repertoires regulate gene expression during limb development in mice and shows that enhancer-promoter interactions dynamically change over time.

The paper identifies essential cardiac enhancer modules and regulatory mechanisms governing heart development, revealing resilience in cis-regulatory architectures and the role of Hand2 upstream regulatory intervals.

The paper compares bat and mouse limb development using single-cell analyses to show how a conserved gene program is repurposed in bat wing formation.

This study shows that variations in enhancer-promoter interactions at the Pitx1 locus lead to pathogenic activation in variable cell proportions, defining phenotypic severity in Liebenberg syndrome.

The paper shows that activation of an LTR retrotransposon in the embryo leads to viral-like particle production, causing limb malformations through apoptotic cell death.

The paper maps chondrogenic enhancers in limb and axial skeleton development and shows their role in explaining human height heritability.

The paper shows that enhancer function depends on their chromatin context by relocating a distal limb enhancer into a proximal limb TAD, where it loses its distal specificity.

The paper shows that deleting one enhancer of the Pitx1 gene leads to altered cell-specific expression patterns and a clubfoot phenotype due to disrupted enhancer coordination and chromatin changes.

This study identifies a gene desert critical for Shox2 regulation and embryonic survival through enhancer networks in mouse development.

The paper shows that preformed chromatin topology supports robust Shh transcription during limb development, with CTCF and ZRS alleles influencing enhancer-promoter communication.

The paper compares bimodal HoxD gene regulation in chicken and mouse limb development, finding conserved mechanisms with species-specific differences in enhancer activity and TAD boundaries.

The paper identifies genome-wide binding sites of posterior HOX-TFs and reveals subgrouping based on sequence specificity and CTCF association.