Olimpia Bompadre

The paper identifies functional roles of human KZFPs through overexpression screening and integrative analysis, revealing diverse mechanisms in cellular homeostasis.

The paper investigates how temporally restricted enhancer repertoires regulate gene expression during limb development in mice and shows that enhancer-promoter interactions dynamically change over time.

This study shows that variations in enhancer-promoter interactions at the Pitx1 locus lead to pathogenic activation in variable cell proportions, defining phenotypic severity in Liebenberg syndrome.

The paper shows that deleting one enhancer of the Pitx1 gene leads to altered cell-specific expression patterns and a clubfoot phenotype due to disrupted enhancer coordination and chromatin changes.