The circ_0074371/miR-4738-3p/AMPK Signaling Axis Induces M1 Macrophage Polarization and Restricts Intracellular Survival of Mycobacterium tuberculosis
Junai Zhang, Chen-Ye Lian, Yuan-Bin Lu, Shu-Ying Yao, Huan Xu, Yao Xu, Gan-Bing Liu, Guo-Si Chen, Yue-Feng Cen, Yuanting Li, XU Zhuo-lin, Yi-Dan Huang, Guo-Ying Chen, Jia-Jun Wang, Jia-Hua Shi, , Xu Junfa
This study identifies circ_0074371 as a tuberculosis-associated circRNA that regulates AMPK activity and influences macrophage polarization via the miR-4738-3p/AMPK signaling axis, reducing Mtb intracellular survival.
bioRxiv · Oct 26, 2026 · PreprintImmunology