Author

Huan Xu

Anhui University of Science and Technology

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Biology Disciplines

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Bioinformatics· 1 Cancer Biology· 1 Genetics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Zhixiang ReniD· 2 shared Chen-Ye Lian· 1 shared Dingchen Cao· 1 shared Gan-Bing Liu· 1 shared Guangxiang TongiD· 1 shared Guo-Si Chen· 1 shared Guo-Ying Chen· 1 shared Huijie ZhouiD· 1 shared

Activity by Year

2022-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersCancer Biology

Zhixiang RenORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

The circ_0074371/miR-4738-3p/AMPK Signaling Axis Induces M1 Macrophage Polarization and Restricts Intracellular Survival of Mycobacterium tuberculosis

Junai Zhang, Chen-Ye Lian, Yuan-Bin Lu, Shu-Ying Yao, Huan Xu, Yao Xu, Gan-Bing Liu, Guo-Si Chen, Yue-Feng Cen, Yuanting Li, XU Zhuo-lin, Yi-Dan Huang, Guo-Ying Chen, Jia-Jun Wang, Jia-Hua Shi, , Xu Junfa

This study identifies circ_0074371 as a tuberculosis-associated circRNA that regulates AMPK activity and influences macrophage polarization via the miR-4738-3p/AMPK signaling axis, reducing Mtb intracellular survival.

bioRxiv · Oct 26, 2026 · PreprintImmunology

Mechanistic Decoding of Pharmacodynamic Intratumoral Heterogeneity: A Pan-Cancer Regulatory Framework

Zhixiang Ren, Yiming Ren, Zeting Li, Shuang Ge, Yaxin Xu, Huan Xu

The paper decodes pharmacodynamic intratumoral heterogeneity by linking single-cell transcriptomes with drug-response profiles across 24 cancer types, identifying regulatory mechanisms driving differential drug responses.

bioRxiv · Oct 5, 2026 · PreprintCancer Biology

Identification of bioactive constituents for colitis from traditional Chinese medicine prescription via deep neural network

Zhixiang Ren, Yiming Ren, Pengfei Liu, Qi Shu, Huijuan Ma, Huan Xu

The paper uses a deep neural network to identify bioactive constituents in TCM prescriptions for colitis, finding that selected compounds effectively suppress disease progression in mice.

bioRxiv · May 31, 2023 · PreprintBioinformatics

Generate a new crucian carp (Carassius auratus) strain without intermuscular bones by knocking out bmp6

Youyi Kuang, Xianhu Zheng, Dingchen Cao, Zhipeng Sun, Guangxiang Tong, Huan Xu, Ting Yan, Shizhan Tang, Zhongxiang Chen, Tingting Zhang, Tan Zhang, Le Dong, Xiaoxing Yang, Huijie Zhou, Weilun Guo, Xiaowen Sun

This paper generates a crucian carp strain without intermuscular bones by knocking out bmp6, showing improved growth and beneficial muscle metabolites.

bioRxiv · Nov 28, 2022 · PreprintGenetics