O-GlcNAc clusters attenuate BRD4 phase separation for transcription regulation
Guojian Shao, Qidong Deng, Tianyu Wang, Cuihua Li, Na Wang, Jun Liu, Yun Ge
This study shows O-GlcNAc clusters modulate BRD4 phase separation, affecting transcription by altering condensate properties and gene expression programs.
bioRxiv · Oct 20, 2025 · PreprintBiochemistry