Jun Liu

Molecular grammar of RNA m6A modification in ribonucleoprotein granules

The paper uses SMART-epi to study how m6A modification affects RNP granule assembly and RNA interactions, revealing functional divergence among YTHDF proteins.

O-GlcNAc clusters attenuate BRD4 phase separation for transcription regulation

This study shows O-GlcNAc clusters modulate BRD4 phase separation, affecting transcription by altering condensate properties and gene expression programs.

YTHDF2 upregulation and relocation dictate CD8 T cell polyfunctionality in tumor immunity

This paper shows YTHDF2 upregulation and nuclear relocation enhance CD8 T cell polyfunctionality and tumor immunity by regulating gene transcription and mitochondrial fitness.

A Conformation-specific Nanobody Targeting the NMN-activated State of SARM1

The paper develops a nanobody that specifically targets the NMN-activated state of SARM1, enabling structural analysis and functional studies of this conformation.

Model-based analysis of positive selection significantly expands the list of cancer driver genes, including RNA methyltransferases

driverMAPS improves cancer driver gene detection by modeling positive selection and mutation patterns, identifying 159 new potential driver genes including RNA methyltransferases.