A cell-free platform based on nisin biosynthesis for discovering novel lanthipeptides and guiding their overproduction in vivo
Ran Liu, Yuchen Zhang, Guoqing Zhai, Shuai Fu, Xia Yao, Ben Hu, Xuan Cai, Yan Zhang, Yan Li, Zixin Deng, Tiangang Liu
The paper develops a cell-free platform for discovering and overproducing lanthipeptides by combining genome mining with screening assays, identifying novel compounds and improving production efficiency.
Advanced Science · Jul 21, 2020Peer-reviewedSynthetic Biology