Shuai Fu

This paper creates a multimodal single-cell atlas of the human basal ganglia, revealing epigenomic and 3D genome features across cell types and linking them to disease-associated genetic risk.

The paper identifies PBX1 as a convergent target of autism risk genes that influences neural progenitor cell proliferation in ASD.

The paper uses lineage tracing in human cortical organoids to show that most neurons arise from intermediate progenitors and that genetic variants affect lineage-specific transcriptional profiles and neuron diversity.

The paper shows that a PTEN p.I135L mutation and an ASD genetic background together disrupt cortical neurogenesis in iPSC-derived NPCs and organoids.

The paper develops a cell-free platform for discovering and overproducing lanthipeptides by combining genome mining with screening assays, identifying novel compounds and improving production efficiency.