Mutant huntingtin exon-1 impaired GTPCH and DHFR expression in plants and mice
Chiu‐Yueh Hung, Chuanshu Zhu, Farooqahmed S. Kittur, Maotao He, Erland Arning, Jianhui Zhang, Asia J. Johnson, Gurpreet S. Jawa, Michelle D. Thomas, Tomas T. Ding, Jiahua Xie
This study shows that mutant huntingtin exon-1 with expanded polyQ tracts impairs GTPCH and DHFR expression in plants and mice, affecting C1 and BH4 metabolism linked to HD pathogenesis.
bioRxiv · May 18, 2022 · PreprintMolecular Biology