Molecular BiologybioRxivPreprint
Mutant huntingtin exon-1 impaired GTPCH and DHFR expression in plants and mice
Chiu‐Yueh Hung, Chuanshu Zhu, Farooqahmed S. Kittur…·Jiahua Xie
This study shows that mutant huntingtin exon-1 with expanded polyQ tracts impairs GTPCH and DHFR expression in plants and mice, affecting C1 and BH4 metabolism linked to HD pathogenesis.
DOI 10.1101/2022.05.18.492514