Noncannonical functions of Ku may underlie essentiality in human cells
Rachel D. Kelly, Gursimran Parmar, Laila Bayat, Matthew E. R. Maitland, Gilles Lajoie, David R. Edgell, Caroline Schild‐Poulter
This study establishes a conditional Ku70 knockout system in human cells to investigate the causes of Ku essentiality, finding that loss of Ku affects multiple cellular processes beyond DNA repair and telomere maintenance.
Scientific Reports · Jul 27, 2023Peer-reviewedMolecular Biology