Gilles Lajoie

HR3/RORα-mediated cholesterol sensing regulates TOR signaling

The paper identifies HR3/RORα as a conserved cholesterol sensor that activates the TOR pathway in Drosophila and human cells, linking cholesterol availability to growth regulation.

Cell State Chaos Underpins the Evolution of SMARCA4-Deficient Dedifferentiated Endometrial Cancer

This study shows that SMARCA4 loss in endometrial cancer leads to cell state chaos, not stemness, causing dedifferentiation through epigenomic dysregulation.

Proteomic Signatures of Podocyte Injury Are Reflected in Urinary Extracellular Vesicles in Pediatric Nephrotic Syndrome.

The paper identifies proteomic differences in urinary extracellular vesicles from pediatric nephrotic syndrome patients during active disease versus remission, linking them to podocyte injury.

Syngeneic adipose-derived stromal cells modulate the immune response but have limited persistence within decellularized adipose tissue implants in C57BL/6 mice

This study shows syngeneic adipose-derived stromal cells (ASCs) modulate early macrophage responses but are cleared by 2 weeks in DAT implants, with no long-term regenerative impact.

A chemical probe to modulate human GID4 Pro/N-degron interactions

The paper introduces PFI-7, a chemical probe that inhibits GID4 Pro/N-degron interactions, revealing non-degradative roles of the CTLH complex in human cells.

Interplay between β-propeller subunits WDR26 and muskelin regulates the CTLH E3 ligase supramolecular complex

The paper shows that the CTLH E3 ligase complex regulates substrate selectivity and autoregulation by exchanging its β-propeller subunits WDR26 and muskelin.

Noncannonical functions of Ku may underlie essentiality in human cells

This study establishes a conditional Ku70 knockout system in human cells to investigate the causes of Ku essentiality, finding that loss of Ku affects multiple cellular processes beyond DNA repair and telomere maintenance.

Never in Mitosis Kinase 2 regulation of metabolism is required for neural differentiation

This study shows Nek2 regulates neural differentiation by controlling metabolism, specifically preventing HIF1 stabilization to enable oxidative phosphorylation.

Lactate Accelerates Mouse ES Cell Differentiation Towards the XEN Lineage

This study shows lactate promotes XEN cell differentiation in mouse embryos by enhancing glycolytic activity and lactate accumulation.

Embryonic Protein NODAL Regulates the Breast Tumour Microenvironment by Reprogramming Cancer-Derived Secretomes

This study shows NODAL reprograms cancer cell secretomes to influence fibroblast activation and MSC recruitment in breast cancer.