Evidence for conservation of primordial 12-hour ultradian gene program in humans under free-living conditions.
Bokai Zhu, Silvia Liu, Natalie L. David, William A. Dion, Nandini K. Doshi, Lauren B Siegel, Tânia Amorim, Rosemary E. Andrews, GV Naveen Kumar, Hanwen Li, Saad Irfan, Tristan Pesaresi, Ankit X. Sharma, Michelle Sun, Pouneh K. Fazeli, Matthew L. Steinhauser
The paper identifies robust ~12h transcriptional rhythms in human peripheral white blood cells under free-living conditions, showing homology to circatidal gene programs in marine species.
bioRxiv · May 2, 2023 · PreprintSystems Biology