Matthew L. Steinhauser

This study identifies alanine as a critical metabolite regulated by TGF-β that supports myofibroblast differentiation in pulmonary fibrosis through GPT2 and SLC38A2.

This study develops a covalent peptide targeting NEDD9-SH3 to inhibit endothelial migration and fibroproliferative remodeling in PAH by stabilizing the RT loop and modulating sulfatase-1 activity.

The paper identifies robust ~12h transcriptional rhythms in human peripheral white blood cells under free-living conditions, showing homology to circatidal gene programs in marine species.

The paper shows that inhibiting lactate transporters MCT1 and MCT4 reduces myofibroblast differentiation and pulmonary fibrosis in vitro and in vivo.

This study shows that transducing gluconeogenic enzymes into retinal cells delays cone photoreceptor loss and visual decline in retinitis pigmentosa models, regardless of the genetic cause.

This study shows Yap regulates glucose utilization and nucleotide synthesis to support organ growth in zebrafish, with conserved mechanisms in mammals.