Bokai Zhu

This study identifies RBBP5 as an essential epigenetic regulator of the 12h oscillator and proteostasis, linking it to metabolic and cellular homeostasis in mammals.

This study identifies AHCY as a key driver of epigenetic and metabolic reprogramming in ZFTA-RELA ependymomas, revealing its role in promoting tumor growth through pyrimidine synthesis and asparagine dependency.

This study identifies SOLAR as a lysosomal quality control pathway that links CASM to p62-driven membrane repair and redox signaling, with implications for aging and degenerative disease.

This study identifies pyrvinium pamoate as a compound that rejuvenates nuclear speckles, improving protein quality control and reducing YAP1 activity, thereby alleviating proteinopathies in pre-clinical models.

This study shows that lipoatrophy in female mice leads to beige fat recruitment, which improves metabolic outcomes but reduces fertility.

The paper identifies LEF1 isoforms as key regulators of cellular senescence and aging through transcriptomic analysis and validation in human and mouse models.

The paper identifies robust ~12h transcriptional rhythms in human peripheral white blood cells under free-living conditions, showing homology to circatidal gene programs in marine species.

The paper identifies 12-hour ultradian rhythms in the human prefrontal cortex and shows disruptions in schizophrenia affecting genes related to protein processing and mitochondrial function.

The paper shows XBP1s regulates 12h-transcriptome rhythms in liver, aligning with central dogma information flow, and identifies GABP as a novel regulator.