Transcriptional boosting and buffering during neurodevelopment by shifts in mRNA instability
Marat Mufteev, Deivid C. Rodrigues, Gwyneth Bolter, Kyoko E. Yuki, Ashrut Narula, Wei Wei, Alina Piekna, Jiajie Liu, Peter Pasceri, Olivia S. Rissland, Brett Trost, Michael D. Wilson, James Ellis
The paper measures transcription rate and mRNA half-life changes during human neuronal development and identifies transcriptional buffering as the most prevalent mode of gene regulation.
bioRxiv · Mar 1, 2023 · PreprintMolecular Biology