Olivia S. Rissland

The paper identifies a ubiquitin network that maintains enterocyte identity by degrading stem-cell related translational machinery, which is disrupted with aging.

This study identifies RBP47 family members as negative regulators of heat stress tolerance in Arabidopsis by showing their role in sequestering 40S ribosomal subunits and limiting translational restart.

The paper shows that stress granules sequester the CCR4-NOT complex, leading to poly(A) tail lengthening and increased survival transcript abundance under stress.

The paper identifies a new N-degron pathway regulated by UBR4 and MetAP2, targeting specific N-terminal arginine and lysine residues after methionine removal.

The paper identifies Muskelin as a substrate adaptor for the Drosophila CTLH E3 ligase, showing how it regulates the degradation of RNA-binding proteins during the maternal-to-zygotic transition.

The paper shows that nonoptimal codon usage represses translation initiation, reducing protein levels independently of transcript abundance or stability.

The paper investigates how mRNA half-life buffers transcription rate changes in Rett syndrome models, identifying post-transcriptional mechanisms in human and mouse neurons.

The paper measures transcription rate and mRNA half-life changes during human neuronal development and identifies transcriptional buffering as the most prevalent mode of gene regulation.

The paper characterizes transcriptome dynamics during the Drosophila MZT using RNA-seq data, revealing zygotic isoforms with distinct regulatory potential and proteomic consequences.

The paper uses long-read sequencing to analyze poly(A) signals in Giardia lamblia, revealing a unique AGURAA signal and alternative polyadenylation events.

This study determines the structure of the Giardia lamblia 80S ribosome, revealing evolutionary divergence in translation and quality control mechanisms compared to other eukaryotes.

The paper shows that egg activation triggers the degradation of maternally deposited RNA binding proteins via the ubiquitin-proteasome system, mediated by Kondo and CTLH ligase.

The paper shows that codon usage and amino acid identity significantly influence mRNA stability in humans, affecting protein abundance through translational elongation rates.

The paper investigates mRNP organization and shows that mRNA compaction changes with translational state and that mRNAs are not translated in a closed-loop conformation.

DRUID is a computational pipeline that improves the reproducibility of mRNA stability measurements using intron dynamics for normalization.