Wei Wei

Population-scale drug target and variant prioritization with Varformer

Varformer prioritizes drug targets and variants by integrating variant and gene features using a transformer model, achieving high precision across diverse benchmarks.

Navigating Human Astrocyte Differentiation: Direct and Rapid one-step Differentiation of Induced Pluripotent Stem Cells to Functional Astrocytes Supporting Neuronal Network development

This study presents a one-step protocol to differentiate hiPSCs into functional astrocytes, enabling co-culture with neurons to support network development.

MitoPerturb-Seq identifies common and gene-specific single-cell responses to mitochondrial DNA depletion and heteroplasmy

Hypersynchronous iPSC-derived SHANK2 neuronal networks are rescued by mGluR5 agonism

This study shows that SHANK2 variants cause hypersynchronous neuronal network activity in human iPSC-derived neurons, which is rescued by mGluR5 agonism.

Disease-linked mutations dysregulate neuronal condensate physical properties, composition, and RNA translation

The paper shows that disease-linked shank2 mutations alter condensate physical properties and composition, leading to aberrant RNA translation.

Buffering of transcription rate by mRNA half-life is a conserved feature of Rett syndrome models

The paper investigates how mRNA half-life buffers transcription rate changes in Rett syndrome models, identifying post-transcriptional mechanisms in human and mouse neurons.

Transcriptional boosting and buffering during neurodevelopment by shifts in mRNA instability

The paper measures transcription rate and mRNA half-life changes during human neuronal development and identifies transcriptional buffering as the most prevalent mode of gene regulation.

Using the UniFrac metric on Whole Genome Shotgun data

This paper develops a method to compute the UniFrac metric on Whole Genome Shotgun metagenomic data by assigning branch lengths to taxonomic trees, showing it is robust and comparable to traditional 16S UniFrac.

Identification of TIA1 mRNA targets during human neuronal development

The paper identifies TIA1 mRNA targets during human neuronal development and shows that TIA1 binding is associated with translation repression and neurodevelopmental gene regulation.

Metabolic shift underlies recovery in reversible infantile respiratory chain deficiency

The paper identifies a metabolic shift involving amino acid availability and mitochondrial biogenesis as the mechanism underlying recovery in reversible infantile respiratory chain deficiency.

Control iPSC lines with clinically annotated genetic variants for versatile multi-lineage differentiation

The paper describes the generation of genetically annotated iPSC lines from healthy donors and demonstrates their use in creating disease-relevant cell types and identifying variant-preferred lines for control in disease modeling.