3-phenyllactic acid promotes healthspan through SKN-1/ATFS-1-mediated mitochondrial activation and stress resilience
Juewon Kim, Yunju Jo, Gyumin Lim, Yosep Ji, Jonghwa Roh, Wan-Gi Kim, Hyon‐Seung Yi, Dong Wook Choi, Donghyun Cho, Dongryeol Ryu
This study identifies 3-phenyllactic acid (PLA) as a metabolite from lactic acid bacteria that extends healthspan in C. elegans by enhancing mitochondrial function and stress resilience, and links PLA levels to sarcopenia in humans.
bioRxiv · Nov 13, 2023 · PreprintMolecular Biology