H. A. Shaban

Genome-wide analysis of the dynamic and biophysical properties of chromatin and nuclear proteins in living cells with Hi-D

The paper introduces Hi-D-Py, a Python-based implementation of Hi-D for analyzing chromatin and nuclear protein dynamics in living cells, reducing analysis time significantly.

Individual transcription factors modulate both the micromovement of chromatin and its long-range structure

This study shows that individual transcription factors modulate both local chromatin mobility and long-range chromatin structure in living cells.

Spatially coherent diffusion of human RNA Pol II depends on transcriptional state rather than chromatin motion

The paper investigates RNA Pol II movement in human cells, finding that its spatial coherence depends on transcriptional state rather than chromatin motion.

Hi-D: Nanoscale mapping of nuclear dynamics in single living cells

Hi-D maps nanoscale chromatin and nuclear protein dynamics in single cells using fluorescence imaging and Bayesian inference, revealing spatially partitioned DNA motion patterns.

Formation of correlated chromatin domains at nanoscale dynamic resolution during transcription

This paper introduces DFCC to quantify chromatin motion correlations in living cells, revealing long-range spatial correlations and domain transitions during transcription.

Real-time chromatin dynamics at the single gene levelduring transcription activation

This study uses real-time imaging to show that transcription initiation rapidly confines a gene's chromatin domain, independent of RNA polymerase elongation.