Mapping Structural Distribution and Gating-Property Impacts of Disease-Associated Missense Mutations in Voltage-Gated Sodium Channels
A. Akbari Ahangar, E. Elhanafy, H. Blanton, J. Li
This study maps disease-associated missense mutations in voltage-gated sodium channels and shows that their effects on channel function are more nuanced than traditional gain-of-function or loss-of-function classifications.
bioRxiv · Sep 20, 2023Biophysics