Increased frequencies of IgH locus suicide recombination points on Chronic Lymphocytic Leukemia with low rate of AID related somatic mutations, cMYC overexpression and short telomeres
I. Al Jamal, M. Parquet, H. Boutouil, K. Guiyedi, D. Rizzo, M. Dupont, M. Boulin, C. El Hamel, J. Lerat, S. Aoufouchi, S. Al Hamaoui, N. Makdissy, J. Feuillard, N. Gachard, S. Peron
The paper identifies a subgroup of CLL patients with increased IgH locus suicide recombination (LSR) rates, linked to low AID expression, short telomeres, and high cMYC expression, suggesting an AID-independent mechanism for LSR.
bioRxiv · Mar 6, 2022 · PreprintCancer Biology