M. Dupont

Apoptosis-mediated ADAM10 activation removes a mucin barrier promoting T cell efferocytosis

The paper shows that ADAM10-mediated removal of mucins during T cell apoptosis enhances macrophage efferocytosis.

The RBPome of influenza A virus mRNA reveals a role for TDP-43 in viral replication

The paper identifies RBPs associated with influenza A virus NP mRNA and shows TDP-43's role in viral replication through mRNA binding and polymerase interactions.

Increased frequencies of IgH locus suicide recombination points on Chronic Lymphocytic Leukemia with low rate of AID related somatic mutations, cMYC overexpression and short telomeres

The paper identifies a subgroup of CLL patients with increased IgH locus suicide recombination (LSR) rates, linked to low AID expression, short telomeres, and high cMYC expression, suggesting an AID-independent mechanism for LSR.

A δ-cell subpopulation with a pro-β-cell identity confers efficient age-independent recovery in a zebrafish model of diabetes

The paper identifies a δ-cell subpopulation in zebrafish that can efficiently convert into insulin-producing cells, offering insights for diabetes treatment.

Plasma microbiome in COVID-19 subjects: an indicator of gut barrier defects and dysbiosis

The paper analyzes plasma microbiome and permeability markers in COVID-19 patients and healthy controls, finding higher gut permeability and gram-negative bacteria abundance in patients.

The RNA sensor MDA5 detects SARS-CoV-2 infection

The paper identifies MDA5 as a cellular sensor for SARS-CoV-2 infection that induces type I and III interferons in Calu-3 cells.

Tuberculosis-associated IFN-I induces Siglec-1 on tunneling nanotubes and favors HIV-1 spread in macrophages

This study identifies Siglec-1 as a factor induced by TB-associated IFN-I that localizes on TNTs and promotes HIV-1 spread in macrophages.

Selective LXR agonist, DMHCA, corrects the retina-bone marrow axis in type 2 diabetes

This study shows that DMHCA, a selective LXR agonist, corrects the retina-bone marrow axis in type 2 diabetes by restoring retinal function, cholesterol homeostasis, and hematopoietic stem cell balance.

Pharmacological and fasting-induced activation of SIRT1/LXRα signaling alleviates diabetes-induced retinopathy.

This study shows that activating SIRT1 signaling through fasting or pharmacology reduces diabetes-induced retinopathy by improving cholesterol metabolism, reducing inflammation, and preserving neural function.